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The Institute for Protein Design(IPD) at the University of Washington in Seattle is creating a new world of synthetic proteins to address 21st-century challenges in medicine, energy, and technology. The IPD is a unique interdisciplinary environment where world-class researchers with expertise in computing and software, biochemistry, genome sciences, biological structure, pharmacology, immunology and other basic science disciplines, as well as clinical medicine, work together to both computationally design and experimentally characterize novel biomolecules. Current projects include the design of novel therapeutics for cancer, neurological diseases, and more, as well as new vaccines, nanomaterials, and enzymes.
The Biochemistry Department has an outstanding opportunity for a Research Scientist 3.
The Research Scientist 3 - Nanoparticle Production Core will perform professional work in support of scientific research in protein production and biophysical characterization of computationally designed proteins. The research activities involve leading production of nanoparticle vaccine candidates and nanoparticle components at the IPD.
RESPONSIBILITIES: In this role, 80% of effort will be dedicated to the production and management of ongoing nanoparticle projects. The remaining 20% of the effort will be dedicated to training and mentoring of direct and indirect reports.
1. Collaboration with numerous researchers at the IPD in the production of designed self-assembling protein nanoparticles and their components, including preparation of detailed Certificates of Testing and/or reports.
2. Participates in complex projects with uncertain outcomes requiring analysis from multiple perspectives.
3. Uses expert knowledge and judgment to develop new methods and techniques for obtaining solutions EM characterization of de novo designed proteins and protein nanomaterials.
4. Manage the activities of two (2) entry level technical support staff along with a minimum of one (1) part time undergraduate support person.
5. Directs projects with undefined time lines and uncertain outcomes requiring analysis from multiple perspectives.
6. Uses expert knowledge and judgment to develop new methods and techniques for obtaining solutions.
REQUIREMENTS: Bachelor's degree in Protein Biochemistry or Bioengineering + 3 or more years of experience in related field to include: experience in protein expression, purification, and characterization; and experience in hands nanoparticle production and characterization. •This position requires that the Research Scientist 3 be capable of selecting and applying standardized scientific procedures and techniques to assignments of moderate complexity, involving potentially conflicting design requirements. • Technical proficiency, scientific creativity, collaborative ability as well as independent thought. • Recognized as a resource for others to use in dealing with protein expression, purification, and characterization. • In-depth understanding of organizational structure both within and outside the work unit, including the role of each position in the group and in other groups. • Ability to develop innovative processes to achieve goals. Directs others to develop essential tasks. Reviews work activities to determine where new information could improve processes or move projects forward. • Ability to select and apply standardized scientific procedures and techniques to assignments of moderate complexity, involving potentially conflicting design requirements.
Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.
DESIRED EXPERIENCE The ideal Research Scientist 3 in Nanoparticle Production Core will be someone who (i) selects and applies standardized scientific procedures and techniques to assignments of moderate complexity, (ii) continually learns and develops methods, (iii) can manage individual research projects that they own, (iv) knows or can learn how to operate current purification and characterization instruments at the IPD, (v) can accurately process negative stain EM imaging data, (vi) and has a deep desire to train others as a mentor in all of these areas, so that others within the IPD can successfully manufacture nanoparticles following efficient standard operating procedures. • Expertise in protein structural characterization by negative stain EM methods. • Expertise in computational protein design using Rosetta • Familiarity in vaccine efficacy study design, in order to contribute to the design of immunogenicity and efficacy studies for vaccine candidates. • Familiarity with GLP practices, including Certificates of Testing and batch records.
Application Process: The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Workforce Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
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