Research - Laboratory/Non-Laboratory, Staff/Administrative
Responsible for scientific and administrative activities and oversight of a core laboratory specializing in next generation T cell receptor sequencing technologies. Will make significanty intellectual contributions in a specialized core facility and will assist users with experimental planning and data interpretation. Co-author/author publications. Contribute original thoughts, hypotheses, and analysis to write reports, abstracts and manuscripts. This individual will have significant input in research design and data collection and interpretation based on advanced knowledge/ understanding of the core activities.
DUTIES AND RESPONSIBILITIES
Will lead day-to-day operations of an established TCR sequencing core within the Sidney Kimmel Comprehensive Cancer Center
Generates sequencing libraries and runs next generation sequencing using the iSeq100 and MiSeq platforms
Develops and validates next generation MANAFEST assay platforms
Assists in assay preparation and data analysis
Supports research and development for new clinical diagnostic tests, therefore must clearly understand the importance of technique, safety, and work quality as they relate to the impact upon patient care.
Reviews techniques and research protocols to ensure reproducibility and issues recommendations.
Documents results under quality assurance guidelines.
Resolves DNA yield/purity/quality problems that are connected with reagent preparation, dilution, expiration dates, and other procedural functions.
Works with laboratory staff to evaluate their technical knowledge and skills, and assists in the training of other laboratory personnel.
Acts as a lead technical authority overseeing laboratory staff and is responsible for the overall daily operation of the laboratory including workload and personnel scheduling, quality control, inventory, and equipment maintenance.
Assists with the development and administration of laboratory budgets. Performs other related administrative and professional duties.
Acts as the direct point of contact for industrial supplier sales personnel and technical support. Prepares periodic reports on workflow for laboratory faculty Director and BKI leadership.
Required: Bachelor's degree in biology, chemistry or related field.
Preferred: Master's or PhD degree in immunology, biology, chemistry or related field.
JHU Equivalency Formula: 30 undergraduate degree credits (semester hours) or 18 graduate degree credits may substitute for one year of experience.
Additional related experience may substitute for required education on the same basis. For jobs where equivalency is permitted, up to two years of non-related college course work may be applied towards the total minimum education/experience required for the respective job.
Four years of related experience required.
Special Knowledge, Skills, or Abilities / Competencies:
Experience with quality control, assay troubleshooting, and SOP development.
Experience in a CLIA-certified lab or pharma environment is desirable.
Extensive experience with human tissue handling, T cell culture, high-yield DNA and RNA isolation, and analysis of T cell receptor sequencing data preferred.
Knowledge and understanding of T cell biology, especially as it relates to the T cell receptor, is desirable but not required
Good verbal and written skills
Attention to detail is a must
Some knowledge of bioinformatics and coding languages preferred
Ability to adapt to changing SOPs
Ability to multi-task in a fast-paced environment
Classified Title: Sr. Research Specialist Working Title: Sr. Research Specialist Role/Level/Range: ACRP/04/MC Starting Salary Range: $45,196 - $62,225, commensurate with experience Employee group: Full Time Schedule: M-F 8:30am- 5:00pm Exempt Status: Exempt Location: 04-MD:School of Medicine Campus Department name: 10002927-Cancer Immunology Lab Research Personnel area: School of Medicine
The successful candidate(s) for this position will be subject to a pre-employment background check.
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