Applications are solicited for an individual to be appointed as a research associate under the supervision of Prof. Dr. Dirk Trauner. The research will focus on the design, synthesis, and biological evaluation of photoresponsive Eg5 inhibitors thus enabling modulation between states of high and low biological activity solely through the action of light. This will be achieved by incorporating of azobenzene moieties into the structures of known inhibitors. In addition to regular azobenzenes we aim to employ dibenzodiazocines, which are novel photoswitches with unique properties. After successful proof of concept, these photoswitchable Eg5 inhibitors will open new approaches tocancer treatmentand could furthermore be used as a tool tostudy basic cellular functions. The additional projects will include the development of synthetic strategies towards complex natural products.
Successful applicants will be highly motivated with an interest in working in organic chemistry and must hold a Ph. D. in organic chemistry or in a related field. The ideal candidate will have research experience in methodology/catalysis, total synthesis, chemical biology, along with a proven track record of solving complex problems.
To be considered, all applicants must submit a cover letter summarizing research experience and specifying the interests in this position; a curriculum vitae (including a full list of publications); a statement of research interests; and two letters of reference.
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