Research - Laboratory/Non-Laboratory, Staff/Administrative
Position in the Department of Oncology Analytical Pharmacology Core Laboratory (APC). The main focus of this laboratory is to determine the concentration of drugs and their metabolites in blood and tissue from clinical or preclinical experiments. This position will be filled by a person who will be responsible for running analytical methods for drug analysis.
Specific Duties & Responsibilities
The person in this position will work under supervision performing the following primary duties and responsibilities of the job:
Operates basic laboratory equipment such as centrifuge, pH meter, analytical balance, incubator, scintillation counter and/or utilizes laminar flow hood.
Operates lab computers for data entry.
Prepare all reagents necessary for experiments and use proper sterile techniques to avoid contamination.
Use various techniques for sample preparation such as protein precipitation, liquid liquid extraction and SPE.
Operate the UPLC/MS/MS to complete sample analysis for small molecules in various matrices and species (human, mouse, rabbit, plasma and tissue). Once analytical run is complete, analyze and interprets data and export results into excel file. Adapts and/or modifies experimental methods based upon interpretation of data.
Develop UPLC/MS/MS method under supervision.
Complies with biohazard/radiation safety standards through proper handling of potentially hazardous chemical and biological agents and/or radiation sources in the workplace.
Completes annual university biohazard/universal precaution/radiation safety training, as appropriate.
Uses universal safety precautions to protect self and co-workers from biohazardous materials, including blood-borne pathogens.
Monitors inventory levels, orders materials and supplies in accordance with established policies and procedures, counts orders upon receipt.
Complies with the appropriate technical quality controls of all clinical pharmacology test results within the Cancer Center.
Documents all work performed in accordance with laboratory SOPs. In addition, creates, modified, and interprets laboratory SOPs.
Follows and stays up-to-date FDA/GLP guidelines to sample validation and analysis.
Assist with incoming studies samples to ensure samples submitted are labeled correctly and they are all accounted for. Put sample information into database to track and store samples at proper conditions. Maintains specimen database.
Performs entry-level pharmacokinetic analysis under supervision.
Contribute to writing peer reviewed manuscripts and grants.
Equipment, Machine, or Tool Requirements - Daily use of LC/MS instrumentation. Intermittent use of general laboratory instrumentation including but not limited to centrifuges, solid-phase extraction manifolds, evaporator, balances, pH meter, shaker, water bath, chemical fume hood, biological cabinet.
Bachelor's degree in biology, chemistry or related field required.
Requires a minimum of 1 year of laboratory experience performing relevant techniques
Master's degree, with related graduate research, may substitute for experience to the extent permitted by the JHU equivalency formula:
* JHU Equivalency Formula: 18 graduate degree credits may substitute for one year of experience. For jobs where equivalency is permitted, up to two years of non-related college course work may be applied towards the total minimum education/experience required for the respective job. *
Special Knowledge, Skills, and Abilities
The position requires excellent verbal and written communication skills
Experience using Microsoft Office software required, specifically word and excel. Experience with Analyst software preferred.
Ability to work as a team.
Experience with literature search and problem solving.
Experience with HPLC, UPLC, and mass spectrometry coupled with a general knowledge of chemical sciences required; particularly chemistry, sample extraction and preparation for LC/MS analysis.
Classified Title: Research Specialist Working Title: Research Specialist Role/Level/Range: ACRP/03/MA Starting Salary Range: $33,545 - $46,095; Commensurate with Experience Employee group: Full Time Schedule: Monday-Friday, 8:30am-5:00pm, Up to 37.5 hrs/week Exempt Status: Non-Exempt Location: 04-MD:School of Medicine Campus Department name: 10002932-SOM Onc Analytical Pharmacology Core Personnel area: School of Medicine
The successful candidate(s) for this position will be subject to a pre-employment background check.
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The following additional provisions may apply depending on which campus you will work. Your recruiter will advise accordingly.
During the Influenza ("the flu") season, as a condition of employment, The Johns Hopkins Institutions require all employees who provide ongoing services to patients or work in patient care or clinical care areas to have an annual influenza vaccination or possess an approved medical or religious exception. Failure to meet this requirement may result in termination of employment.
The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.
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